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Analytical Methods in Human Toxicology: Part 2 by Alan S. Curry

By Alan S. Curry

This number of 9 essays by way of best gurus considers the appliance of the main lately constructed analytical thoughts and gear to specific poisons and medicine. It describes using HPLC, fluorescence research, and radioimmunoassays in toxicology and exhibits equipment particular to forensic drugs.

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Extra resources for Analytical Methods in Human Toxicology: Part 2

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Factor 0f 0). e. 5_ . g. 5 which are poorly retained and elute close to the 'solvent front'. Column efficiency is greatest for compounds with k values between 2 and 6, since k values greater than 6 indicate excessively long analysis times (Majors 1974) .

Certain analyses have to be carried out to regulatory authority standards but even if these do not apply , it is important that the principles of 'good laboratory practice' (GLP) are adhered to. A major requirement is that the organisation of the laboratory , and the capabilities, training and responsibilities of the personnel are documented. All apparatus should be regularly calibrated and maintained and only used by authorised personnel. Standard operating procedures (SOPs) for the use of equipment and for specific analytical methods should be written and authorised.

Handbook of Derivatives for Chromatography. Heyden, Bristol, 457-99. , Hohn, B. , and Small, G. W. (1979). J. Chromo Sci. 17,423. , and Dobashi, A. (1979). Adv. Chromo 17, 571-80. Hillcoat , B. , McCulloch, P. , and Williams, C. K. O. (1976). Brit. J. Pharmacol. 3, 135-43. , Smith, E. , and Kellie, A. E. (1975). J. Steroid Biochem. 6 ,91. Horlick, G. (1984) . Analyt. Chem. 56,278. Jones , C. R. (1976). In Reid, E. ). Assay of Drugs and Other Trace Compounds in Biological Fluids, Vol. 5, Methodological Surveys in Biochemistry .

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