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Advances in Prostaglandin and Leukotriene Research: Basic by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

This quantity is the lawsuits of the eleventh overseas convention on Advances in Prostaglandin and Leukotriene learn: easy technology and New medical purposes, held in Florence, Italy, on June 4-8, 2000, which keeps the culture of overlaying either easy and scientific features of prostaglandin and leukotriene examine.

At this assembly specific emphasis was once given to the aptitude program of the radical COX-2 inhibitors, the genetics of bronchial asthma on the subject of the creation of leukotrienes, and novel mobile networks for the construction of leukotrienes and lipoxins.

Traditionally, as has been performed in prior conferences of this sequence, a large amount of new fabric was once offered and mentioned this yr, with specific awareness given to the latest medical data.

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Extra resources for Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

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Crystal structure of a calciumphospholipid binding domain from cytosolic phospholipase A2 • J Biol Chem 1998;273: 1596-1604. Nalefski EA, Falke JJ. The C2 domain calcium-binding motif: structural and functional diversity. Protein Sei 1996;5:2375-90. Reddy KV, Hammarberg T, Rädmark 0. Mg2+ activates 5-lipoxygenase in vitro: dependencyon concentrations ofphosphatidylcholine and arachidonic acid. Biochemistry 2000:39: 1840-48. REGULATION OF PEROXIDASES CELLULAR 5-LIPOXYGENASE ACTIVITY BY GLUTATHIONE Dietlind Schumann, Oliver Werz, Dagmar Szellas, and Dieter Steinhilber B-Iymphocytes, monocytes, and partially differentiated human leukemic celllines express 5-lipoxygenase protein but no concomitant cellular activity.

5LO binds Ca2+ in a reversible manner with a Kd dose to 6 11M and maximum binding around two Ca2+ per 5LO [1]. While examining the Ca2+ binding site on 5LO, we noticed similarity between the 5LO N-terminal domain, and calcium binding C2-domains of for example cPLA2• Here, we describe that the N-terminal domain of 5LO binds calcium and mediates calcium stimulation of enzyme activity. 7, Molsoft LLC). In support ofthe model (Figure 1) residues not conserved between 5LO and 15LO, as weH as gaps, are found mainly in the loops connecting the eight ß-strands.

Biochem Biophys Res Commun 1992; 189:1043-49. Riddick CA, Serio KJ, Hodulik CR, Ring WL, Regan MS, Bigby TD. TGF-beta increases leukotriene C4 synthase expression in the monocyte-like cellline, THP-1. J Immunol 1999; 162:1101-7. , Petersen J, Austen KF. Eosinophils altered phenotypically and primed by culture with granulocyte/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP. J Clin Invest 1991;87:1958-63. Cowburn AS, Sladek K, Soja J, et al. Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.

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